Robert Mealer (2018)

Throughout residency I relied heavily on the RCP for mentorship, as well as support in protecting time to pursue my research interests. As a PGY1, this allowed me to meet with researchers across the many campuses with affiliations to our program. As a PGY2, I spent 7 weeks doing a research rotation in the lab of a leading molecular neuroscientist learning techniques that could be applied to future projects. Finally, as a PGY3 and PGY4, the RCP allowed me to dedicate the majority of my time (50% and 75%, respectively) toward my research project, establishing collaborations and generating preliminary data to use in my K-award application. During my PGY4 year, I was also able to serve as the chief of the McLean Clinical Evaluation Center, and received outside funding for my research from the Stanley Center for Psychiatric Genetics. Without the RCP I would be significantly delayed in moving forward with my research career, and have found the experience both rewarding and invaluable.

After residency I plan to work full-time as a research fellow at MGH and the Stanley Center for Psychiatric Genetics. My research focuses on the cellular and biochemical mechanisms underlying SNPs linked to schizophrenia through large-scale genomic analyses of disease (GWAS). By analyzing biological samples from patients with Schizophrenia, we hope to identify biomarkers for disease or endophenotypes/subpopulations of patients based on genotype with the goal of eventually developing novel tests or treatments for this disorder. I will continue to be supported by Stanley Center Psychiatric Genetics and Neuroscience Fellowship, as well as the Translational Neuroscience Training for Clinicians T32 Fellowship at MGH. I am currently in the process of applying for independent funding from the NIMH to launch me closer towards the ultimate goal of being an independent academic psychiatrist researching the molecular basis of psychiatric illness.


Johns Hopkins University School of Medicine, M.D., Ph.D., 2014

Montana State University, B.S., 2005


Subramaniam, S., Mealer, R.G., Sixt, K.M., Barrow, R.K., Usiello, A., & Snyder S.H.. Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9. Journal of Biological Chemistry. 2010 Jul; 285(27): 20428-20432. Cited in PubMed; PMID: 20424159.

Jin, L., Baker, B., Mealer, R., Cohen, L., Pieribone, V., Pralle, A., & Hughes, T.. Random insertion of split-cans of the fluorescent protein venus into Shaker channels yields voltage sensitive probes with improved membrane localization in mammalian cells.. Journal of Neuroscience Methods. 2011 Jul; 199(1): 1-9. Cited in PubMed; PMID: 21497167.

Subramaniam, S., Napolitano, F., Mealer, R.G., Kim, S., Errico, F., Barrow, R., Shahani, N., Tyagi, R., & Snyder, S.H.. Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nature Neuroscience. 2011 Dec; 15(2): 191-193. Cited in PubMed; PMID: 22179112

Mealer, R.G., Subramaniam, S., & Snyder, S.H.. Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease.. Journal of Neuroscience. 2013 Feb; 33(9): 4206-4210. Cited in PubMed; PMID: 23447628.

Mealer RG, Murray AJ, Shahani N, Subramaniam S, Snyder SH. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. J Biol Chem. 2014 Feb 7;289(6):3547-54. doi: 10.1074/jbc.M113.536912.


2016 NIMH Outstanding Resident Award

2011 Second Place in Graduate Student Association Poster Contest, Johns Hopkins University School of Medicine

2007 Walker Award for Medical Student Research, Department of Psychiatry, Johns Hopkins University School of Medicine