Anna Wiste (2016)

As a PGY-4 resident in the RCP, I worked with Roy Perlis, developing skills in risk prediction and machine learning using electronic health records. My plan is to go into child fellowship next year. My current projects all involve a dataset we’ve generated with all visits to our ED by children for psychiatric issues. There are a number of outcomes that are interesting to look at. Length of stay, hospitalization, repeat visits. The clinical experience working in APS really informs this work, and now when I get frustrated at how tough ED visits are for kids, I know that in my own way I’m doing something about it. This work has all been done with Roy and with Laura Prager.

Both research and clinical interests lie mostly in development of mood disorders across childhood and adolescence. Working with young adult patients has made me really interested in normal and abnormal patterns of mood regulation in this group. They seem to have a lot more variability, and also a lot more trouble describing it. With that interest in this age group, I’m acting as a senior resident with the transitional age youth and child eval rotation for PGY-3s. Its been great fun to get involved with administrative and education roles.

My research history is fairly varied. I started with EHR and risk prediction in the months before I started residency. My first research lab did postmortem brain work in suicide and mood disorders. Then I did a little bit of brain imaging and moved on to genetics. My PhD was training in Iceland in complex genetics. Then after finishing medical school I came to MGH for a post-doc in psychiatric genetics.

Anna Wiste


Emory University, M.D., Ph.D., 2010
Columbia University, B.A., 2001


Tang YL, Wiste A, Mao PX, Hou YZ. Attitudes, knowledge, and perceptions of Chinese doctors toward drug abuse. J Subst Abuse Treat. 2005 Oct;29(3):215-20.

von Brevern M, Ta N, Shankar A, Wiste A, Siegel A, Radtke A, Sander T, Escayg A. Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4. Headache. 2006 Jul-Aug;46(7):1136-41.

Kearney JA*, Wiste AK*, Stephani U, Trudeau MM, Siegel A, RamachandranNair R, Elterman RD, Muhle H, Reinsdorf J, Shields WD, Meisler MH, Escayg A. Recurrent de novo mutations of SCN1A in severe myoclonic epilepsy of infancy. Pediatr Neurol. 2006 Feb;34(2):116-20.

Ling SH, Tang YL, Jiang F, Wiste A, Guo SS, Weng YZ, Yang TS. Plasma S-100B protein in Chinese patients with schizophrenia: comparison with healthy controls and effect of antipsychotics treatment. J Psychiatr Res. 2007 Jan-Feb;41(1-2):36-42.

Wiste AK, Arango V, Ellis SP, Mann JJ, Underwood MD. Norepinephrine and serotonin imbalance in the locus coeruleus in bipolar disorder. Bipolar Disord. 2008 May;10(3):349-59.

Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, Manolescu A, Thorleifsson G, Stefansson H, Ingason A, Stacey SN, Bergthorsson JT, Thorlacius S, Gudmundsson J, Jonsson T, Jakobsdottir M, Saemundsdottir J,Olafsdottir O, Gudmundsson LJ, Bjornsdottir G, Kristjansson K, Skuladottir H,Isaksson HJ, Gudbjartsson T, Jones GT, Mueller T, Gottsäter A, Flex A, Aben KK, de Vegt F, Mulders PF, Isla D, Vidal MJ, Asin L, Saez B, Murillo L, Blondal T, Kolbeinsson H, Stefansson JG, Hansdottir I, Runarsdottir V, Pola R, Lindblad B, van Rij AM, Dieplinger B, Haltmayer M, Mayordomo JI, Kiemeney LA, Matthiasson SE, Oskarsson H, Tyrfingsson T, Gudbjartsson DF, Gulcher JR, Jonsson S, Thorsteinsdottir U, Kong A, Stefansson K. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008 Apr 3;452(7187):638-42.

Tyrfingsson T, Thorgeirsson TE, Geller F, Runarsdóttir V, Hansdóttir I, Bjornsdottir G, Wiste A, Jonsdottir GA, Oskarsson H, Gudbjartsson D, Stefansson K. Addictions and their familiality in Iceland. Ann NY Acad Sci. 2010 Feb;1187:208-17

Wiste A, Robinson EB, Milaneschi Y, Meier S, Ripke S, Clements CC, Fitzmaurice GM, Rietschel M, Penninx BW, Smoller JW, Perlis RH. Bipolar polygenic loading and bipolar spectrum features in major depressive disorder. Bipolar Disord. 2014 Sep;16(6):608-16. doi: 10.1111/bdi.12201.