Michael Murphy (2016)

I came to MGH/McLean after completing my M.D. and Ph.D. at the University of Wisconsin. For my PhD, I worked with Giulio Tononi to study the electroencephalographic (EEG) correlates of sleep and anesthesia. My work showed a functional role for the default mode network in producing and propagating the characteristic EEG waveforms of slow wave sleep. During residency, I have worked with Robert Stickgold at Beth-Israel Deaconess Medical Center to study sleep dependent memory consolidation. I have also been able to explore my clinical interests during the PGY-4. I am a chief resident in the Acute Psychiatry Service at Massachusetts General Hospital and a member of the On Track Program, a first episode psychosis clinic at McLean Hospital. Following residency, I plan to continue my research by examining the relationship between large scale changes in cortical connectivity and transient fluctuations in symptom intensity in patients with psychosis. The overarching goal of this research is to better understand the neurophysiological correlates of state changes in patients in order to identify future targets for therapeutic intervention.



Education

UW-Madison, M.D., 2012
UW-Madison, Ph.D., 2010
UW-Madison, B.S., 2002

Publications

Struck, A.F., Murphy, M.J., & Iskandar, B.J. (2006). Spontaneous development of a de novo suprasellar arachnoid cyst. Journal of Neurosurgery: Pediatrics, 104(6), 426-428.

Ferrarelli, F., Huber R., Peterson, M.J., Massimini, M., Murphy, M., Riedner, B.A., Watson, A., Bria, P., & Tononi, G. (2007). Reduced sleep spindle activity in schizophrenia patients. American Journal of Psychiatry, 164(3), 483-492.

Massimini, M., Ferrarelli, F., Esser, S.K., Riedner, B.A., Huber, R., Murphy, M., Peterson, M.J., & Tononi, G. (2007). Triggering sleep slow waves by transcranial magnetic stimulation. Proceedings of the National Academy of Sciences, 104(20), 8496-8501.

Riedner, B.A., Vyazovskiy, V.V., Huber, R., Massimini, M., Esser, S., Murphy, M., & Tononi, G. (2007). Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep, 30(12), 1643-1657.

Ferrarelli, F., Massimini, M., Peterson, M., Riedner, B., Lazar, M., Murphy, M., Huber, R., Rosanova, M., Alexander, A., Kalin, N., & Tononi, G. (2008). Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients. American Journal of Psychiatry, 165(8), 996-1005.

Murphy, M., Riedner, B.A., Huber, R., Massimini, M., Ferrarelli, F., & Tononi, G. (2009). Source modeling sleep slow waves. Proceedings of the National Academy of Sciences, 106(5), 1608-1613.

Massimini, M., Ferrarelli, F., Murphy, M., Huber, R., Riedner, B., Casarotto, S., & Tononi, G. (2010). Cortical reactivity and effective connectivity during REM sleep in humans. Cognitive Neuroscience, 1(3), 176-183.

Ferrarelli, F., Peterson, M.J., Sarasso, S., Riedner, B.A., Murphy, M.J., Benca, R., Bria, P., Kalin, N., & Tononi, G. (2010). Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles. American Journal of Psychiatry, 167(11), 1339-1348.

Riedner, B.A., Hulse B.K., Murphy, M.J., Ferrarelli, F., & Tononi, G. (2011). Temporal dynamics of cortical sources underlying spontaneous and peripherally evoked slow waves. Progress in Brain Research, 193, 201-218.

Langheim, F.J.P., Murphy, M., Riedner, B.A., & Tononi, G. (2011). Functional connectivity in slow-wave sleep: Identification of synchronous cortical activity during wakefulness and sleep using time series analysis of electroencephalographic data. Journal of Sleep Research, 20(4), 496-505.

Murphy, M., Bruno, M.A., Riedner, B.A., Boveroux, P., Noirhomme, Q., Landsness, E.C., Brichant, J.F., Phillips, C., Massimini, M., Laureys, S., Tononi, G., & Boly, M. (2011). Propofol anesthesia and sleep: A high-density EEG study. Sleep, 34(3), 283-291.

Murphy, M., Huber, R., Esser, S., Riedner, B.A., Massimini, M., Ferrarelli, F., Ghilardi, M.F., & Tononi, G. (2011). The cortical topography of local sleep. Current Topics in Medicinal Chemistry, 11(19), 2438-2446.

Barrett, A.B., Murphy, M., Bruno, M.A., Noirhomme, Q., Boly, M., Laureys, S., & Seth A.K. (2012). Granger causality analysis of steady-state evoked electroencephalographic signals during propofol-induced anesthesia. PLoS ONE, 7(1), e29072.

Boly, M., Moran, R., Murphy, M., Boveroux, P., Bruno, M.A., Noirhomme, Q., Ledoux, D., Bonhomme, V., Brichant, J.F., Tononi, G., Laureys, S., & Friston, K. (2012). Connectivity differences underlying spectral EEG changes during propofol-induced loss of consciousness. Journal of Neuroscience. 32 (20), 7082-7090.