William Ruzicka (2012)

I am a PGY4 Resident in the Research Concentration Program. I am based at McLean Hospital and working in Dr. Francine Benes’ Lab at McLean Hospital where I am investigating the role of DNA methylation in the perturbation of GABAergic cell function in the human hippocampus in schizophrenia and bipolar disorder. I received my MD and PhD in Molecular Genetics at The University of Illinois at Chicago.

Brad's Senior Talk, presented on Wednesday, June 6, 2012, was entitled "Nature, Nurture, and Chromatin Structure."



Univ of Illinois, Chicago, M.D., Ph.D., 2008
Univ of Illinois, Chicago, B.S., 1999


Ruzicka, B, Subburaju, S, Benes, F. Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid–Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder. JAMA Psychiatry. Published Online March 4, 2015. doi:10.1001/jamapsychiatry.2015.49.

Costa E, Chen Y, Dong E, Grayson DR, Kundakovic M, Maloku E, Ruzicka W, Satta R, Veldic M,Zhubi A, Guidotti A. GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Review of Neurotherapeutics 2009 9(1): 87-98.

Costa E, Dong E, Grayson DR, Guidotti A, Ruzicka W, Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics. 2007 Jan-Mar;2(1):29-36. Epub 2007 Feb 27.

Ruzicka WB, Zhubi A, Veldic M, Grayson DR, Costa E, Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol Psychiatry. 2007 Apr;12(4):385-97. Epub 2007 Jan 30.

Guidotti A, Ruzicka W, Grayson DR, Veldic M, Pinna G, Davis JM, Costa E. S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. Neuroreport. 2007 Jan 8;18(1):57-60.

Costa E, Dong E, Grayson DR, Ruzicka WB, Simonini MV, Veldic M, Guidotti A. Epigenetic targets in GABAergic neurons to treat schizophrenia.  Adv Pharmacol. 2006;54:95-117.

Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, Guidotti A. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.  Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17095-100. Epub 2002 Dec 12.


American Psychiatric Association Research Colloquium for Junior Investigators Travel Award 2011