Evan Macosko (2014)

I am a third-year psychiatry resident in the research concentration at MGH-McLean. I received my medical degree from Cornell Medical College, and my PhD from Rockefeller University, where I worked with Cori Bargmann on genetic and circuit-level studies of social behavior in the genetic model organism C. elegans.  My work characterized a collection of oxygen- and pheromone- sensitive neurons that work in concert to regulate worm aggregation.  The work combined genetics, molecular biology, and calcium imaging techniques.

I have joined Steve McCarroll's lab in the Harvard Medical School Genetics Department. Steve's lab is interested in understanding the biological impact of risk alleles that have been recently identified in neuropsychiatric disease, with a particular emphasis on copy number variants.  I plan to develop single-cell genetic and expression-profile techniques to provide molecular insight into how a genetic lesion affects the function of particular cell types or circuits in the human brain.


Weill Cornell Medical College, M.D., 2010
Rockefeller University, Ph.D., 2009
Harvard College, B.A., 2003


Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, Tirosh I, Bialas AR, Kamitaki N, Martersteck EM, Trombetta JJ, Weitz DA, Sanes JR, Shalek AK, Regev A, McCarroll SA. Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets. Cell. 2015 May 21;161(5):1202-14.

Garrison JL, Macosko EZ, Bernstein S, Pokala N, Albrecht DR, Bargmann CI.
Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior. Science. 2012 Oct 26;338(6106):540-3.

Jang H, Kim K, Neal SJ, Macosko E, Kim D, Butcher RA, Zeiger DM, Bargmann CI, Sengupta P. Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans. Neuron. 2012 Aug 23;75(4):585-92.

Macosko, E, Pokala, N, Feinberg, E, Chalasani, S, Butcher, R, Clardy, J, Bargmann, C. A Hub-and-Spoke Circuit Drives Pheromone Attraction and Social Behaviour in C. elegans. Nature 2009, 458, 1171-1175.

McGrath, P, Rockman, M, Zimmer, M, Jang, H, Macosko, E, Kruglyak, L, Bargmann, C. Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. elegans Sensory Behaviors. Neuron 2009, 61, 692-699.

Styer, K, Singh, V, Macosko, E, Steele, S, Bargmann, C, Aballay, A. Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Science 2008, 322, 460-464.

Hengst, U, Cox, L, Macosko, E, Jaffrey, S. Functional and Selective RNA Interference in Developing Axons and Growth cones. Journal of Neuroscience 2006, 26, 5727-5232.

Wu, K, Hengst, U, Cox, L, Macosko, E, Jeromin, A, Urquhart, E, Jaffrey, S. Local Translation of RhoA Regulates Growth Cone Collapse. Nature 2005, 436, 1020-1024.


2012 NIMH Outstanding Resident Award